Malakoplakia is a chronic inflammatory condition defined by the presence of Michaelis-Gutmann bodies and von Hansemann histiocytes . Previous case reports most commonly describe these lesions in the genitourinary tract, but rare case reports also reported presence in the gastrointestinal tract which is thought to be the most common location outside of the genitourinary tract . Other studies have suggested an association with immunosuppressed patients . We present a rare finding of locally aggressive malakoplakia in a patient that underwent liver transplantation that presented with a large, infiltrative colonic mass.Pathology from the rectal polyp removed during colonoscopy returned positive for cytomegalovirus (CMV) and he was started on valgancyclovir. Pathology from the right hemicolectomy with partial duodenectomy revealed a large (10.8 cm in greatest dimension) submucosal inflammatory mass that involved the ascending colon and extended into the duodenal wall; the mass consisted of heavy histiocytic and lymphoplasmacytic infiltrates, focal granulomata and focal microabscesses . A CD 68 immunohistochemical stain highlighted numerous Von Hanseman histiocytes, while a Von Kossa special stain highlighted the numerous round, laminated basophilic bodies, containing calcium in their cores, consistent with Michaelis Gutman bodies, staples for malakoplakia. Immunohistochemical stains for CMV, herpes simplex virus (HSV) I&II, Adenovirus were performed on several blocks and were negative