Malakoplakia is a chronic inflammatory condition defined by the presence of Michaelis-Gutmann bodies and von Hansemann histiocytes [1,2]. Previous case reports most commonly describe these lesions in the genitourinary tract, but rare case reports also reported presence in the gastrointestinal tract which is thought to be the most common location outside of the genitourinary tract [3,4]. Other studies have suggested an association with immunosuppressed patients [5]. We present a rare finding of locally aggressive malakoplakia in a patient that underwent liver transplantation that presented with a large, infiltrative colonic mass.