Coronavirus is rapidly spreading over the world and is continuously doing havoc. According to studies, cytokine storms and T-helper abnormalities play a key role in the majority of acute cases of the condition. A variety of drugs have been recommended to treat or control the condition, but they have all been withdrawn due to negative effects. Melatonin, as an intrinsic molecule, has pharmacological anti-inflammatory and antioxidant capabilities, but its concentration diminishes with age, making older people more susceptible to numerous ailments. The COVID-19 outbreak raises serious concerns about vaccine efficacy for those taking the anti-CD20 drug ocrelizumab. The humoral response to SARS-CoV-2 infection and vaccination has been demonstrated to be reduced by ocrelizumab, although the T-cell response to vaccination has yet to be fully defined [1]. We wanted to see what B and T-cell responses to SARS-CoV-2 vaccination looked like in ocrelizumab-treated patients, and what characteristics correlated with vaccine immunogenicity. PwMS receiving glatiramer acetate, Interferon-ß, Dimethyl fumarate, Cladribine or Natalizumab had intact humoral and cellular immune responses following vaccination against SARS CoV-2. B-cell depleting therapies reduced B-cell responses but did not affect T cell responses. Sphingosin-1-Phospate (S1P) inhibitors strongly reduced humoral and cellular immune responses.We reasoned that patients who did not have a humoral response to the SARS-CoV-2 vaccine would nevertheless have healthy T-cell responses. Selenium, an essential trace element, is critical for human health and, in particular, for the proper functioning of the immune system. Se deficit in COVID-19 patients was linked to disease severity and death risk during the current epidemic. Selenium has been linked to a positive immunological response after vaccination, although it’s unclear whether this holds true for SARS-CoV-2 vaccinations. The immunological factors involved in protection against SARS-CoV-2 infection are not well defined or understood [2]. Previous knowledge of the related SARS virus and other human coronaviruses, on the other hand, may be valuable. Anti-SARS-CoV-2 antibodies measured in population-based serosurveys could give a pattern for assessing infection levels and tracking the epidemic’s progression. To combat the COVID-19 pandemic brought on by SARS-CoV-2 infection, significant progress has been achieved in identifying infected individuals and detecting those who have a positive immunological response to the virus. Attempts to develop a vaccine against the coronavirus are now underway