The global pandemic of Sars-Cov-2 promoted 566 million infected and more than 6.3 million deaths, around the world. However, after infection, sequelae may appear, often persisting for more than 12 weeks, called post-COVID 19 sequelae, of systemic origin (fatigue and asthenia), respiratory (dyspnea and persistent cough), neuropsychiatric (memory loss, imbalance, anosmia, ageusia and anxiety) and musculoskeletal (myalgia and joint pain). In this context, new technologies and methodologies are developed for the treatment of these sequelae, often with the synergistic use of photonic, ultrasonic and negative pressure resources. In this work, 4 cases of patients with post-Covid 19 sequelae were gathered, from the most varied origins. They were followed up in evolution, varying the number of treatment sessions from case to case. The treatment carried out through these non-invasive and non-drug resources (laser, ultrasound and negative pressure) enabled the complete rehabilitation of these patients, returning their quality of life.