COVID-19 pandemic, induces a viral protein called open reading frame 3b(ORF3b) actively blocks the induction of type I interferon which are polypeptides that are secreted by infected cells antiviral defense called interferon, that produced by sick cells originally from ribosomal functions, which plays a really important role in slowing virus infection. Interferon is considered to be the initiative primary messages started from ribosome in the infected cells to follow the right original biological pathways to reach brain for asking for protection, recoveries and facing the viral infection