Gastric most cancers are a heterogeneous malignant ailment related to environmental and genetic predisposing elements. While gastric most cancers prevalence and mortality fell significantly globally during the last decades, it stays the fourth motive of most cancers-associated dying worldwide. Thus, prevention of gastric most cancers remains a chief method for development of gastric most cancers prognosis. Helicobacter pylori contamination has been validated to be a chief chance component for the improvement of gastric most cancers. Unhealthy weight loss program and lifestyle, together with high-salt meals, smoking and drinking, are capable of set off genotypic and phenotypic transformation of gastric epithelial cells. Gene mutations (together with E-cadherin) in belly epithelial cells are most important genetic reasons for gastric most cancers. The eradication of H. pylori has been validated to be a powerful technique for number one prevention of gastric most cancers. Increased consumption of a weight loss program wealthy in veggies and sparkling end result in addition to smoking cessation were proven to lessen the prevalence of gastric most cancers. The secondary prevention method is to display premalignant gastric lesions with the aid of using endoscopy. Biomarker exams also are dependable techniques to perceive gastric precancerous lesions. Endoscopy screening remains the gold well known for prognosis of gastric most cancers.