Cancer can be managed with different therapies of them gene induced therapy is a procedure intended to treat a disease by genetically modifying the cell of the patient. Genes, gene segments or oligonucleotides are transferred into patient cells. Gene transfer therapy can be done either in vivo approach or ex vivo approach. Gene therapy aims to modify, delete or replace abnormal gene of the target cell. Target cells may be malignant primarily or metastatic nodules, circulating tumour cells or dormant stem cells or specific cells such as T-cell lymphocytes or dendritic cells