Objective: This review discusses current findings in the subject and addresses the clinical relevance of Non-HLA antibodies.
Methods: This traditional narrative review used PubMed and Medline searches for English language reports on Non HLA abs during last 20 years. The search included the key words: non-human leukocyte; antibodies; kidney; transplantation.
Results: 65 related articles and review were found.
Conclusion: Non-HLA immunity is associated with poor graft survival, rejection and chronic graft loss. Moreover, they could be used as biomarkers of ongoing immune response and as predictors of graft failure.