Climate change is one of the global issues which we must of necessity tackle with urgency to ensure sustainable economic growth and development in Africa. Climate change, global warming and other related environmental challenges presently pose as a threat to sustainable economic growth in Africa. However, these environmental challenges have also created opportunities for green entrepreneurship in Africa. Through literature and participant observation, it has been discovered that there is great need for communities, cities and countries in Africa to adopt the green entrepreneurship which is ecofriendly and has capacity to provide green skills, green technology and green jobs for sustainable economic growth. This paper identifies the great need for communities and institutions in Africa to engage in a more intensive research and disruptive innovation approach to devise the means of ensuring a cleaner and healthier environment by proper waste management strategies which will help to guarantee sustainable environment and sustainable economic growth in Africa. Proper waste management is also a climate change mitigation strategy to ensure a sustainable future where economies can thrive and good health is fostered across every border. This paper also highlights the urgent need and innovative ways to educate communities and institutions in Africa about climate change mitigation for sustainable development which involves the reduce, reuse and recycling of waste products which is therefore very vital to ensure that our environment is a cleaner and greener place to live.