Background: Sexual health is an important aspect of Quality of life (QoL). It is a basic human right and a fundamental part of a full healthy life. Patients with Chronic kidney disease (CKD) world-wide suffer many physical dysfunctions including sexual activity. Psychological impacts may also contribute to changes in sexual functioning and further complicate CKD patients’ problems. Therefore, this study aims to assess the relationship between psychosexual dysfunctions experienced by hemodialysis male patients and their evaluation of their QoL. Methods: A descriptive correlational research design is conducted in the hemodialysis units at Urology and Nephrology Center at Mansoura University.